Major Uses

Amitriptyline is used to treat separation anxiety in dogs and cats. The drug can be given to help prevent nervous behavior such as inappropriate urination in cats and obsessive grooming behavior in both dogs and cats. In some cases, Amitriptyline is also used to treat lower urinary tract disease in cats.

Common Precautions

Side effects most commonly associated with Amitriptyline are drowsiness and sedation. Dry mouth and constipation can occur. Amitriptyline should be used with caution in pregnant animals or those with seizure disorders. To prevent possible drug interactions, a veterinarian should be informed of all other medications the pet is taking.

Amitriptyline should not be administered in animals with a known allergy or hypersensitivity to the drug. Emergency veterinary care should be sought if an animal experiences any unusual symptoms.


Oral suspension should be refrigerated. All other forms should be kept at room temperature away from sunlight. The injectable form should be protected from freezing.


Amitriptyline is available in a tablet, oral suspension, injectable, and transdermal gel.

A typical dose range for Amitriptyline in dogs is 1-2mg/kg PO q12; Doses may vary in different species, when the drug is given by a different route or concurrently with other medications, and with regards to a patient's age, breed, and health status. A veterinarian's dosing instructions and/or those printed on the medication label should be followed closely.

If a dose is missed, it should be administered as soon as possible. If it is almost time for the subsequent dose, the missed dose should be skipped and the regular dose administration schedule resumed. Two doses of Amitriptyline should not be administered at the same time.

This information is for general reference only and should not be used for the diagnosis or treatment of any condition of your pet. It's intended as a general reference, this information may not include all possible uses, precautions, directions, reactions (including allergic), drug interactions, or withdrawal times. Always consult your local veterinarian and have your pet examined for any advice concerning the diagnosis and treatment of your pet, including which products and doses are most appropriate. Any trademarks are the property of their respective owners. VetDepot is not a pharmacy. All prescription products are dispensed by our Pharmacy Partner. Article last updated 2/2014.