Chlorpromazine

Major Uses

Chlorpromazine is most commonly used to reduce nausea and vomiting in dogs and cats. In some cases, this drug is used as a moderate sedative. Chlorpromazine works by blocking dopamine receptors in the nervous system, but the exact mechanism of its action is not fully understood.

Common Precautions

Side effects most commonly associated with Chlorpromazine are constipation, sedation, and low blood pressure. Chlorpromazine should not be administered in animals with glaucoma or low blood pressure. Chlorpromazine should be used with caution in animals with liver disease or heart disease.

Chlorpromazine should not be administered in animals with a known allergy or hypersensitivity to the drug. Chlorpromazine may interact with other medications including barbiturates, propranolol, narcotics, and some anti-diarrheal medications. This should be discussed with a veterinarian. Emergency veterinary care should be sought if an animal experiences any unusual symptoms.

Storage

Chlorpromazine tablets and capsules should be stored in a tight container at room temperature and out of direct sunlight. Injectable forms and oral solution should be kept from freezing, and stored at room temperature.

Administration

Chlorpromazine is available in the following forms:

10mg, 25mg, 50mg, 100mg, and 200mg tablets

30mg, 75mg, 150mg, 200mg, and 300mg extended release capsules

25mg and 100mg rectal suppositories

2mg/ml syrup and 30mg/ml concentrate both in 120ml bottles

25mg/ml injectable concentration in 1ml, 2ml, and 10ml

A typical dose range for Chlorpromazine in dogs is 0.5 mg/kg IV, IM or SC three to four times daily for use as an antiemetic. Dose may vary in different species, when the drug is given by a different route or concurrently with other medications, and with regards to a patient's age, breed, and health status. A veterinarian's dosing instructions and/or those printed on the medication label should be followed closely.

If a dose is missed, it should be administered as soon as possible. If it is almost time for the subsequent dose, the missed dose should be skipped and the regular administration schedule resumed. Two doses of Chlorpromazine should not be administered at the same time.