Major Uses

Difloxacin is a fluoroquinolone antibiotic that is used primarily in dogs for treating bacterial infections. It may also be useful in treating dogs with moderate to severe renal failure due to its extensive hepatobiliary excretion and low chance of accumulating toxic levels.

Common Precautions

When used in growing animals, difloxacin can cause arthropathies. Because of this, difloxacin should not be used in dogs 2-8 months old for smaller breeds and 2-18 months old for larger breeds. Caution should be used when administering this drug to animals with known or suspected CNS disorders. Difloxacin may cause nausea and vomiting in cats, and its ophthalmic safety has not yet been determined in the species.

The most common negative side effects associated with difloxacin are anorexia, vomiting, and dairrhea. More negative effects may occur with higher doses.

Difloxacin should not be used in animals with a known allergy or hypersensitivity to the drug. A veterinarian should be contacted immediately if an overdose is suspected, the symptoms of which include facial erythema/edema, decreased appetite, weight loss, and diarrhea.


Difloxacin should be kept at room temperature in a tightly sealed, childproof container and should be kept away from excessive heat. It should be stored where it cannot be reached by children or animals.


For treating susceptible conditions in dogs, a typical dose is 5-10 mg/kg once daily until symptoms disappear. Once symptoms are gone, treatment should continue for an additional 2-3 days. For treating susceptible infections in horses, a typical dose is 7.5 mg/kg once daily. If a dose is forgotten, it should be administered as soon as possible. Should it be nearing time for the next scheduled dose, the missed dose should be skipped and the regularly scheduled dose should be given. Two doses should not be administered at the same time, as an overdose may occur.

Doses may vary in different species, when the drug is given by a different route or concurrently with other medications, and with regards to a patient's age, breed, and health status. A veterinarian's dosing instructions and/or those printed on the medication label should be followed closely.

This information is for general reference only and should not be used for the diagnosis or treatment of any condition of your pet. It's intended as a general reference, this information may not include all possible uses, precautions, directions, reactions (including allergic), drug interactions, or withdrawal times. Always consult your local veterinarian and have your pet examined for any advice concerning the diagnosis and treatment of your pet, including which products and doses are most appropriate. Any trademarks are the property of their respective owners. VetDepot is not a pharmacy. All prescription products are dispensed by our Pharmacy Partner. Article last updated 2/2014.