Major Uses

Dinotefuran, permethrin, and pyriproxyfen are antiparasitic agents that are combined to create a safe and effective topical treatment for dogs to fight against fleas, ticks, mosquitos, and other insects. Dinotefuran kills fleas of all stages, while pyriproxyfen sterilizes them until dinotefuran kills them, and permethrin attacks the nervous system of insects. Dinotefuran kills fleas upon contact; the drug does not need to be ingested by the insect for it to be effective. The product Vectra 3D contains dinotefuran, permethrin, and pyriproxyfen, and this 6-way topical treatment typically will kill insects within six hours of application.

Common Precautions

Side effects with the use of dinotefuran, permethrin, and pyriproxyfen are typically rare and mild, but if any unusual reactions occur, the pet's veterinarian should be contacted. The drug should only be administered to dogs, as it is highly toxic to cats. The drug should not be administered to puppies less than eight weeks of age, and should be used with caution in elderly dogs as well. Dinotefuran, permethrin, and pyriproxyfen should not be administered to pregnant or nursing dogs, and the pet's veterinarian should be consulted first if the animal is sick or medicated. Because possible drug interactions can occur, the pet's veterinarian should be aware of all medications the pet is taking prior to administration.

Dinotefuran, permethrin, and pyriproxyfen should not be administered to animals with a known allergy or hypersensitivity to the drug or other pesticides. Signs of sensitivity may occur at the application site, like redness of the skin, however, the pet's veterinarian should be contacted if any other reactions occur.


The drug should be stored in a cool, dry place, and care should be taken to prevent it from freezing.


Dinotefuran, permethrin, and pyriproxyfen is administered topically to dogs once a month. Depending on the dog's weight, they receive 1-4 drops of the drug applied evenly down the dog's back. It will naturally spread evenly down the body of the dog to provide full coverage. Care should be taken so the medication does not get in the eyes of the pet. Doses may vary in different species, when the drug is given by a different route or concurrently with other medications, and with regards to a patient's age, breed, and health status. A veterinarian's dosing instructions and/or those printed on the medication label should be followed closely.

This information is for general reference only and should not be used for the diagnosis or treatment of any condition of your pet. It's intended as a general reference, this information may not include all possible uses, precautions, directions, reactions (including allergic), drug interactions, or withdrawal times. Always consult your local veterinarian and have your pet examined for any advice concerning the diagnosis and treatment of your pet, including which products and doses are most appropriate. Any trademarks are the property of their respective owners. VetDepot is not a pharmacy. All prescription products are dispensed by our Pharmacy Partner. Article last updated 2/2014.