Major Uses

Eprinomectin is a broad-spectrum antiparasitic medication belonging to the macrocyclic lactone class of endectocides. It is a unique avermectin and is primarily used in beef and dairy cattle.

This drug provides control of internal and external parasites, including lungworms, gastrointestinal roundworms, sucking and biting lice, grubs, chorioptic and sarcoptic mange mites, and horn flies.

Common Precautions

Side effects with correct use of eprinomectin are rare. This is not a guarantee that no adverse reactions will occur.

This medication should not be administered orally or by injection. It is for external application only.

Eprinomectin is not for use on humans or animals other than cattle. Eprinomectin and other avermectins have been known to cause pupil dilation, depression, staggering, blindness, coma, and death in dogs that have ingested or come into direct contact with these drugs. Any suspected contact should be reported to a veterinarian immediately.

Eprinomectin should not be used in animals with a known allergy or hypersensitivity to the drug. Any known or suspected overdose in cattle or other animals should be reported to a veterinarian right away.


Eprinomectin should be stored in its original container and packaging, away from light and extreme temperatures. Temperatures up to 86°F/30°C are acceptable. This drug should be kept away from children and pets.


Eprinomectin is available as an external pour for application along the backline from the withers to the tailhead.

The recommended dose of eprinomectin is 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight. This drug should be applied to all cattle in the herd. Eprinomectin is for external application only.

Doses may vary in different species, when the drug is given by a different route or concurrently with other medications, and with regards to a patient's age, breed, and health status. A veterinarian's dosing instructions and/or those printed on the medication label should be followed closely.

This information is for general reference only and should not be used for the diagnosis or treatment of any condition of your pet. It's intended as a general reference, this information may not include all possible uses, precautions, directions, reactions (including allergic), drug interactions, or withdrawal times. Always consult your local veterinarian and have your pet examined for any advice concerning the diagnosis and treatment of your pet, including which products and doses are most appropriate. Any trademarks are the property of their respective owners. VetDepot is not a pharmacy. All prescription products are dispensed by our Pharmacy Partner. Article last updated 2/2014.