Major Uses

L-deprenyl is an MAO-B inhibitor most commonly used to treat canine and feline cognitive dysfunction syndrome. In some cases, L-deprenyl is used as a treatment for Cushing's disease, although this is not recommended by all veterinarians due it the lack of its efficacy.

Common Precautions

Side effects most commonly associated with L-deprenyl are usually uncommon but may include vomiting, diarrhea, restlessness, or lethargy.

L-deprenyl should not be administered in animals with a known allergy or hypersensitivity to the drug. L-deprenyl may interact with other medications including Tramadol and Amitraz. This should be discussed with a veterinarian. Emergency veterinary care should be sought if an animal experiences any unusual symptoms.


L-deprenyl tablets should be stored in a tight container at a controlled room temperature of 20-25 degrees Celsius.


L-deprenyl is available in 2 mg, 5 mg, 10 mg, and 30 mg tablets.

A typical dose range for L-deprenyl in dogs is 1 mg/kg PO in the AM (with food as needed) for the treatment of Cushing's disease. Dose may vary in different species, when the drug is given by a different route or concurrently with other medications, and with regards to a patient's age, breed, and health status. A veterinarian's dosing instructions and/or those printed on the medication label should be followed closely.

If a dose is missed, it should be administered as soon as possible. If it is almost time for the subsequent dose, the missed dose should be skipped and the regular administration schedule resumed. Two doses of L-deprenyl should not be administered at the same time.

This information is for general reference only and should not be used for the diagnosis or treatment of any condition of your pet. It's intended as a general reference, this information may not include all possible uses, precautions, directions, reactions (including allergic), drug interactions, or withdrawal times. Always consult your local veterinarian and have your pet examined for any advice concerning the diagnosis and treatment of your pet, including which products and doses are most appropriate. Any trademarks are the property of their respective owners. VetDepot is not a pharmacy. All prescription products are dispensed by our Pharmacy Partner. Article last updated 2/2014.