Major Uses

Nitenpyram is an oral insecticide that is commonly used to kill adult fleas on dogs and cats. It may also be effective for treating various kinds of fly larvae.

Common Precautions

Nitenpyram should not be used in animals that weigh less than 2 pounds, or in animals that are less than 4 weeks old.

Negative side effects associated with nitenpyram are rare. Scratching may occur as fleas begin to die. Other possible side effects may include hyperactivity, lethargy, panting, fever, vomiting, vocalization, decreased appetite, diarrhea, salivation, and allergic reactions such as hives, difficulty breathing, incoordination, seizures, increased heart rate, trembling, and pupil dilation.

Nitenpyram should not be used in animals with a known allergy or hypersensitivity to the drug. A veterinarian should be contacted immediately if an overdose is suspected.


Nitenpyram should be kept at room temperature and stored in a tight, light resistant container that is childproof. If stored below 76 degrees Fahrenheit, nitenpyram can last for up to three years before needing to be disposed of.


Nitenpyram can be administered with or without food and as often as once per day for dogs and cats. For dogs, a typical dose can range from 11.4-57 mg depending on weight. For cats, a typical dose is 11.4 mg. When being used to treat maggots in reptiles, 11.4 mg should be crushed and administered as an edema, or on the wound, one time only. For instances in which a dose is forgotten, it should be administered as soon as possible. Should it almost be time for the next scheduled dose, the missed dose should be skipped and the regular dosing schedule should resume. Two doses should not be administered at the same time.

Doses may vary in different species, when the drug is given by a different route or concurrently with other medications, and with regards to a patient's age, breed, and health status. A veterinarian's dosing instructions and/or those printed on the medication label should be followed closely.

This information is for general reference only and should not be used for the diagnosis or treatment of any condition of your pet. It's intended as a general reference, this information may not include all possible uses, precautions, directions, reactions (including allergic), drug interactions, or withdrawal times. Always consult your local veterinarian and have your pet examined for any advice concerning the diagnosis and treatment of your pet, including which products and doses are most appropriate. Any trademarks are the property of their respective owners. VetDepot is not a pharmacy. All prescription products are dispensed by our Pharmacy Partner. Article last updated 2/2014.