Major Uses

Omeprazole is a proton pump inhibitor that is most commonly used for treating GI ulcers and erosions. It has also been used to prevent exercise-induced gastritis in Alaskan sled dogs. An oral form has proven useful in treating and preventing the recurrence of gastric ulcers in horses.

Common Precautions

Side effects associated with omeprazole are rare. However, some patients have developed urticaria after using this drug. Some other potential side effects associated with omeprazole include anorexia, colic, nausea, vomiting, flatulence, diarrhea, hematologic abnormalities, proteinuria, urinary tract infections, and CNS disturbances.

Patients suffering from hepatic or renal disease may require adjustments to the typical dose amount. If these conditions are present, a veterinarian should be contacted for an adjusted dose.

Omeprazole should not be used in animals with a known allergy or hypersensitivity to the drug. A veterinarian should be contacted immediately if an overdose is suspected, symptoms of which may include diarrhea and anemia.


Omeprazole should be kept at room temperature and stored in a tightly sealed, light resistant, childproof container. While it can withstand temperatures of up to 104 degrees Fahrenheit, it should not face prolonged exposure to these temperatures. The capsule form should be protected from crushing.


For the management and prevention of GI ulcers in dogs, a typical dose of omeprazole is .5-1 mg/kg once daily. For cats, a typical dose is between .5-1.5 mg/kg every 12-24 hours. For treating gastric ulcers in horses, a typical dose is 4 mg/kg once daily for 4 weeks, followed by 2 mg/kg once daily for another 4 weeks to prevent recurrence. If a dose is missed, it should be administered as soon as possible. If it is almost time for the next scheduled dose, the missed dose should be skipped and the animal's regular medication schedule should resume. Under no circumstances should two doses be administered at the same time.

Doses may vary in different species, when the drug is given by a different route or concurrently with other medications, and with regards to a patient's age, breed, and health status. A veterinarian's dosing instructions and/or those printed on the medication label should be followed closely.

This information is for general reference only and should not be used for the diagnosis or treatment of any condition of your pet. It's intended as a general reference, this information may not include all possible uses, precautions, directions, reactions (including allergic), drug interactions, or withdrawal times. Always consult your local veterinarian and have your pet examined for any advice concerning the diagnosis and treatment of your pet, including which products and doses are most appropriate. Any trademarks are the property of their respective owners. VetDepot is not a pharmacy. All prescription products are dispensed by our Pharmacy Partner. Article last updated 2/2014.