Major Uses

Trimeprazine with prednisolone is a phenothiazine antihistamine and corticosteroid that is commonly used for treating pruritic conditions. It may also be useful in dogs as an antitussive.

Common Precautions

Caution should be used when administering trimeprazine with prednisolone to animals taking steroids, as symptoms such as weight loss, elevated liver enzymes, polyuria/polydipsia, diarrhea, and vomiting may occur. When being used chronically, Cushing's syndrome may appear. Long-term users should be taken off the drug gradually.

The most common side effects associated with trimeprazine with prednisolone include sedation, hypotension, depression, and extrapyramidal reactions such as tremors, rigidity, weakness, and restlessness. Other negative side effects may include negative nitrogen balance, sodium retention and potassium loss, delayed wound healing, sedation, blood dyscrasias, osteoporosis, and suppressed adrenocortical function.

Trimeprazine with prednisolone should not be used in animals with a known allergy or hypersensitivity to the drug. A veterinarian should be contacted immediately if any of the common symptoms are displayed quickly after medication is administered and an overdose is suspected.


Trimeprazine with prednisolone should be kept at room temperature in a tight, light resistant, childproof container. It should kept away from light and stored where children and pets will not be able to reach it


Trimeprazine with prednisolone commonly comes in tablet form. When being used for antipruritic and antitussive reasons, a typical dose is 1/2 a tab twice daily for animals weighing up to 10 lbs, 1 tablet twice daily for animals weighing 11-20 lbs, 2 tablets twice daily for animals weighing 21-40 lbs, and 3 tablets twice daily for animals weighing more than 41 lbs. After 4 days, all doses should be halved. If a scheduled dose is forgotten, it should be administered as soon as possible. If the next scheduled dose is near, that dose should be given instead of the missed dose. No matter what, two doses should not be administered at the same time.

Doses may vary in different species, when the drug is given by a different route or concurrently with other medications, and with regards to a patient's age, breed, and health status. A veterinarian's dosing instructions and/or those printed on the medication label should be followed closely.

This information is for general reference only and should not be used for the diagnosis or treatment of any condition of your pet. It's intended as a general reference, this information may not include all possible uses, precautions, directions, reactions (including allergic), drug interactions, or withdrawal times. Always consult your local veterinarian and have your pet examined for any advice concerning the diagnosis and treatment of your pet, including which products and doses are most appropriate. Any trademarks are the property of their respective owners. VetDepot is not a pharmacy. All prescription products are dispensed by our Pharmacy Partner. Article last updated 2/2014.